Lub luag haujlwm ntawm D-Serine yog dab tsi?

D-Serine hmoovyog ib qho tshwj xeeb amino kev puas tsuaj uas xav tau ib feem hauv tib neeg txoj kev vam meej, tshwj xeeb tshaj yog nyob rau hauv frontal cortex muaj peev xwm thiab txhim kho. Txawm hais tias tsis tshua muaj txiaj ntsig ntau dua li ob peb lwm cov amino acids, cov khoom no tau txais txiaj ntsig kev tshawb fawb loj vim tias nws txoj kev koom tes hauv cov kab mob hauv nruab nrog cev. Hauv tsab xov xwm no, peb yuav tshuaj xyuas qhov ua tau ntawm D-serine, nws lub peev xwm ntawm lub cev, thiab nws cov ntawv thov kev txhawb nqa.

 

D-Serine yog dab tsi thiab nws nyob qhov twg?

 

Nws yog non-proteinogenic amino destructive, qhov tseem ceeb koom nrog cov proteins hauv hlwb tsis siv. Nyob rau hauv lub teeb ntawm txhua yam, nws mus tej zaum raws li ib tug neuromodulator thiab co-agonist rau N-methyl-D-aspartate receptor (NMDAR), ib hom ionotropic glutamate receptor pom muaj feem ntau nyob rau hauv lub hlwb thiab qaum qaum.

Ib txwm tshwm simD-Serine hmoovyog tsim los ntawm serine racemase, ib qho kev sib xyaw uas hloov L-serine (qhov kev tsim kho ntau dua hauv cov proteins) rau D-serine. Qhov siab tshaj plaws convergences ntawm D-serine yog pom nyob rau hauv lub mammalian lub siab, tshwj xeeb tshaj yog nyob rau hauv cov cheeb tsam uas muaj feem xyuam nrog lub siab lub ntsws muaj peev xwm, xws li lub forebrain thiab hippocampus.

Thaum nws tau sib xyaw ua ke hauv lub siab, ntau cov nyiaj me me kuj tseem muaj nyob hauv cov ntaub so ntswg, nrog rau ob lub raum, daim siab, thiab lub plawv. Txawm li cas los xij, kev cuam tshuam ntawm cov ntshav siab txwv cov ntu ntawm D-serine los ntawm sab nrauv mus rau lub focal sensory system (CNS), pom zoo tias feem ntau D-serine hauv lub paj hlwb yog tsim hauv zos.

 

D-Serine cuam tshuam rau lub hlwb ua haujlwm thiab kev loj hlob li cas?

 

Lub luag haujlwm tseem ceeb ntawm nws hauv siab yog mus ua tus co-agonist rau NMDAR, tus receptor uas yog qhov tseem ceeb rau kev sib txuas lus, kev kawm, thiab kev nco. NMDARs tsis tshua muaj tshwm sim ntawm glutamate receptors nyob rau hauv uas lawv xav tau kev txwv ntawm ob tug agonists - glutamate thiab glycine los yog D-serine - mus rau tag nrho impelled.

Los ntawm kev txwv rau qhov chaw glycine ntawm NMDAR, D-serine ua haujlwm ntawm receptor's antipathy rau glutamate, ua haujlwm nrog rau kev tso dej ntawm calcium hais rau hauv postsynaptic neuron. Qhov dej ntawm calcium no pib ib tug ciav ntawm txoj kev chij uas nws thiaj li ua rau lub zog ntev ntev (LTP), ib qho kev kawm ntawm tes thiab kev loj hlob ntawm kev nco.

Tawg hauvD-Serine hmoovtheem lossis NMDAR muaj peev xwm tau nkag mus rau hauv ntau yam kev puas siab puas ntsws thiab kev loj hlob ntawm lub paj hlwb, suav nrog tus mob schizophrenia, Alzheimer's ailment, thiab qee yam kev cuam tshuam kev kawm. Piv txwv li, cov kev tshawb fawb tau pom tias D-serine qib tau txo qis hauv cov cortex pem hauv ntej ntawm cov tib neeg uas muaj tus mob schizophrenia, uas tuaj yeem ntxiv rau cov kev puas siab puas ntsws tsis zoo thiab cov kev cuam tshuam thib ob cuam tshuam nrog qhov teeb meem.

Txawm hais tias nws txoj haujlwm hauv synaptic pliancy, nws tseem koom nrog cov txheej txheem neurodevelopmental, zoo li neurogenesis (kev taw qhia ntawm cov neurons tshiab), neuronal zog, thiab synaptogenesis (kev npaj ntawm cov neurotransmitters tshiab). Cov qib D-serine txaus thaum lub sij hawm tseem ceeb ntawm kev puas siab puas ntsws yog qhov tseem ceeb rau kev tsim cov kab mob neuronal raug cai thiab kev teeb tsa hauv Circuit Court.

 

D-Serine puas tuaj yeem kho cov kab mob neurological?

 

Muab qhov tseem ceeb ntawm D-serine hauv cerebrum muaj peev xwm thiab kev nce qib, cov kws tshuaj ntsuam tau tshawb xyuas qhov kev xav tau rov qab siv dua ntawm D-serine supplementation hauv cov teeb meem neurological sib txawv. Thaum cov txiaj ntsig tau sib xyaw, qee qhov kev ntsuam xyuas tau pom tias muaj kev pom zoo.

Hauv schizophrenia, ob peb qhov kev kho mob ua ntej tau tshawb fawb txog kev siv D-serine raws li kev kho mob ntxiv rau cov tshuaj tiv thaiv kab mob. Ob peb qhov kev ntsuam xyuas tau qhia txog kev hloov pauv hauv kev puas siab puas ntsws, cov kev mob tshwm sim tsis zoo, thiab feem ntau hais txog kev ua haujlwm thaum D-serine ntxiv rau cov tshuaj tiv thaiv kev puas hlwb. Txawm li cas los xij, qhov sib txawv ua ntej tau tsis quav ntsej los tsim cov kev tshawb pom zoo no, tawm tswv yim tias qhov txaus ntawm D-serine supplementation yuav vam khom raws li tus neeg mob zoo lossis muaj mob subtypes.

Hauv Alzheimer's mob, kev kuaj mob ua ntej tau qhia txog qhov ntawdD-Serine hmoovtuaj yeem txhim kho kev puas siab puas ntsws tsis txaus thiab synaptic tawg nyob rau hauv cov qauv tsim ntawm cov mob. Cov kev tshawb pom no tau ua rau muaj kev soj ntsuam tas li ua ntej tshawb fawb txog kev muaj peev xwm ntawm D-serine raws li tus kws kho mob tshwj xeeb rau Alzheimer's mob, ib leeg lossis sib xyaw nrog kev kho mob sib txawv.

Tsis tas li ntawd, D-serine tau raug tshawb xyuas raws li kev kho mob tshwj xeeb ntawm cov kws tshawb fawb tsis muaj peev xwm thiab cov kab mob neurodevelopmental messes cuam tshuam nrog NMDAR tawg, piv txwv li, D-serine tsis txaus cov teeb meem thiab cov kev mob tshwm sim tsis zoo. Thaum cov ntaub ntawv pov thawj tseem txwv, qee qhov kev ntsuam xyuas tau qhia txog kev txhim kho hauv kev puas siab puas ntsws thiab kev coj ua nrog D-serine supplementation hauv cov xwm txheej no.

Txawm hais tias qhov muaj peev xwm kho tau zoo ntawm D-serine, kuj muaj kev txhawj xeeb thiab kev txwv rau nws txoj kev siv. Feem ntau ntawm D-serine tuaj yeem ua rau muaj kev cuam tshuam tsis zoo, xws li nephrotoxicity (lub raum mob) thiab fringe neuropathy ( paj hlwb). Tsis tas li ntawd, bioavailability ntawm D-serine nyob rau hauv lub cerebrum yog txwv tsis pub vim cov ntshav-lub siab hindrance, yuav tsum tau ntau dua ib feem kom ua tiav cov kev pab tsom hauv CNS.

Cov kws tshawb fawb tab tom tshawb xyuas cov txheej txheem sib txawv los tuav cov kev cuam tshuam no, piv txwv li, loj hlob ntau dua bioavailable D-serine cov phiaj xwm lossis xa D-serine ncaj nraim mus rau cerebrum siv cov txheej txheem kev xa tshuaj.

Xi'an ZB Biotech Co., Ltd yogD-Serine hmoov tsum, peb tuaj yeem muab taud-serine ntsiav tshuajlos yogd-serine ntxiv. Peb lub Hoobkas kuj tuaj yeem muab OEM / ODM Kev Pabcuam Ib-nres, suav nrog kev ntim khoom thiab cov ntawv lo. Yog xav paub ntxiv, koj tuaj yeem xa email rauJessica@xazbbio.comlos yogWhatsApp pawg+8618591943808.

Xaus:

D-Serine hmoovyog ib qho kev ntxim nyiam thiab complex amino corrosive uas xav tias yog ib qho tseem ceeb hauv kev muaj peev xwm thiab kev txhim kho ntawm cerebrum. Nws txoj kev koom tes hauv NMDAR tweak, synaptic versatility, thiab cov txheej txheem neurodevelopmental tau ua rau nws lub hom phiaj ntawm kev kuaj mob hnyav hauv kev taug kev kom nkag siab thiab kho cov kab mob sib txawv thiab cov kab mob neurodevelopmental messes.

Thaum lub peev xwm kho dua tshiab ntawm D-serine supplementation nyob twj ywm qhov chaw ua haujlwm ntawm kev tshuaj xyuas, nrog rau cov txiaj ntsig tau zoo thiab kev txwv, kev tshawb fawb txuas ntxiv mus nthuav tawm kev pom rau hauv cov txheej txheem nyuaj ntawm D-serine cov dej num hauv cerebrum. Raws li peb yuav txhais li cas D-serine txoj haujlwm txuas ntxiv mus, txoj kev tshiab rau kev kho kom haum xeeb thiab kev kho kom haum xeeb yuav tshwm sim, muab kev cia siab rau cov neeg cuam tshuam los ntawm cov xwm txheej tsis zoo no.

 

Cov ntaub ntawv:

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2. Wolosker, H. (2011). Serine racemase thiab serine thauj ntawm vertebrates thiab microscopic kab mob. Biochemical Society Exchanges, 39(1), 244-252.

3. Balu, DT, and Coyle, JT (2015). NMDA receptor 'glycine modulatory site' hauv schizophrenia: D-serine, glycine, thiab tom qab ntawd qee qhov. Kev ntsuas tam sim no hauv Pharmacology, 20, 109-115.

4. Lin, CH, Path, HY, and Tsai, GE (2012). Glutamate motioning nyob rau hauv pathophysiology thiab kev kho mob schizophrenia. Pharmacology Organic chemistry and Conduct, 100(4), 665-677.

5. Madeira, C., Lourenco, MV, Vargas-Lopes, C., Suemoto, CK, Brandão, CO, Reis, T., ... and Laks, J. (2015). d-serine qib hauv Alzheimer tus mob: cov lus qhia rau biomarker tshiab thiab kho qhov rooj qhib. Translational Psychiatry, 5(5), e561.

6. Labrie, V., and Roder, JC (2010). Lub koom haum ntawm NMDA receptor D-serine / glycine site nyob rau hauv pathophysiology thiab kev kho mob ntawm tus mob schizophrenia. Neuroscience and Biobehavioral Audits, 34(3), 351-372.

7. Billard, JM (2015). D-serine nyob rau hauv lub maturing hippocampus. Diary of Drug and Biomedical Examination, 116, 18-24.

8. Kantrowitz, JT, and Javitt, DC (2010). N-methyl-d-aspartate (NMDA) receptor breakness lossis dysregulation: txoj kev ib txwm dhau los tau ncaj nraim mus rau tus mob schizophrenia? Daim Ntawv Ceeb Toom Txog Lub Siab, 83(3-4), 108-121.